Expanding Our Understanding of mtDNA Deletions.
نویسندگان
چکیده
Clonal expansion of mtDNA deletions compromises mitochondrial function in human disease and aging, but how deleterious mtDNA genomes propagate has remained unclear. In this issue (Gitschlag et al., 2016) and in a recent Nature publication, C. elegans studies implicate the mitochondrial unfolded protein response (UPR(mt)) and offer mechanistic insights into this process.
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ورودعنوان ژورنال:
- Cell metabolism
دوره 24 1 شماره
صفحات -
تاریخ انتشار 2016